Equine Vet News Folge 2
Titel:
Managementmaßnahmen und Inhalationstherapie bei equinem Asthma
Beschreibung:
In der zweiten Folge von Equine VetNews sprechen Dr. Anja Gabe und Dr. Victoria Kratzmann über Inhalationstherapie und Managementmaßnahmen bei equinem Asthma. Nach einer kurzen Einführung in das Krankheitsbild, Diagnosemöglichkeiten, akuten Therapiemaßnahmen erläutern wir die für die Behandlung notwendigen Managementmaßnahmen sowie mögliche Inhalationstherapien. Wir befassen uns genauer mit den Ergebnissen der Studie A CONSORT-guided, randomized controlled clinical trial of nebulized administration of dexamethasone and saline on lower airway cytokine mRNA expression in horses with moderate asthma von Bond S., Léguillette R. (2024), https://doi.org/10.1111/jvim.16983. Thema ist die Inhalation von Dexamethasoninjektionslösung und Kochsalzlösung sowie deren Effizienz für Klinik, Zytologie-Ergbenisse der BALF und Expression von mRNA von proinflammatorsichen Zytokinen. Es wird daraufhin genau auf mögliche Inhalationsmedikamente für die Therpie beim equinen Asthma eingegangen. Diese Folge liefert praxisrelevantes Wissen für Therapiemaßnahmen bei equinem Asthma, das direkt in die tägliche Arbeit einfließt.
Liste der Dosierungen für Inhalationsmedikamente
Glukokortikoide: Zur Verbesserung der Klinik und der Lungenfunktion
- Ciclesonid: 2700µg (q12h)-4116µg (24h) MDI-Spray
- Budenosid: 900µg – 1800µg (q 12h) Lösung
- Fluticason 1100µg (q 24-48h) – 1980µg (q12h) MDI-Spray
- Fluticason/Salmeterol 2500µg/250µg (q12h) MDI-Spray
Bronchodilatatoren
- Ipratropiumbromid 1-1,5mg 2-4 x tgl Lösung
- Salmeterol 63-2110µg 2-3x tgl. MDI-Spray
Sonstiges
- Lidoacin HCL
- 1,0mg/kg KW als 4%ige Lösung verdünnt auf 20ml mit 0,9iger NACl-Lösung
- Natriumchromoglykat
- 80mg in 0,02%iger Lösung 1-2x tgl. oder 200mg 1-2xtgl MDI-Spray
MDI- Dosieraerosol oder Metered-Dose Inhaler, KW – Körpergewicht
Quellen
- A CONSORT-guided, randomized, double-blind, controlled pilot clinical trial of inhaled lidocaine for the treatment of equine asthma, Mahalingam-Dhingra A. et al. (2022), https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978287/
- A CONSORT-guided, randomized controlled clinical trial of nebulized administration of dexamethasone and saline on lower airway cytokine mRNA expression in horses with moderate asthma, Bond S., Léguillette R. et al. (2024), https://doi.org/10.1111/jvim.16983
- A Literature Review on Equine Bedding: Impacts on Horse and Human Welfare, Health, and the Environment, Masebo T. et al. (2025), https://www.mdpi.com/2076-2615/15/5/751
- Effect of Management Regime on Airborne Respirable Dust in Horse Stables, Auger J. et al. (2017), https://doi.org/10.1016/j.jevs.2017.07.004
- Randomized, controlled study of inhaled fluticasone propionate, oral administration of prednisone, and environmental management of horses with recurrent airway obstruction, Couëtil LL et al. (2005), https://avmajournals.avma.org/view/journals/ajvr/66/10/ajvr.2005.66.1665.xml
- Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate, Giguère S. et al. (2002), https://pubmed.ncbi.nlm.nih.gov/11943316/
- Environmental Management of Equine Asthma, De Castro E.D. et al. (2024), https://www.mdpi.com/2076-2615/14/3/446
- DELIVERY OF DRUGS INTO THE EQUINE RESPIRATORY TRACT, Funch-Nielsen S. et al., https://doi.org/10.1111/eve.12905
- Effect of different doses of inhaled ciclesonide on lung function, clinical signs related to airflow limitation and serum cortisol levels in horses with experimentally induced mild to severe airway obstruction, Lavoie J.-P. et al., https://doi.org/10.1111/evj.13093
- Efficacy and side effects of long-term inhaled fluticasone for recurrent airway obstruction in horses, Lavoie J., Leclere M., Lavoie-Lamoureux A., Numoz T., Dauvillier J., Flaminio J. (2009), https://www.researchgate.net/publication/266887837_Efficacy_and_side_effects_of_long-term_inhaled_fluticasone_for_recurrent_airway_obstruction_in_horses
- Efficacy of inhaled budesonide for the treatment of severe equine asthma, Lavoie J.-P. et al. (2019), https://doi.org/10.1111/evj.13018
- Equine Asthma: Current understanding and future directions, Couëtil L.L. et al. (2020), https://doi.org/10.3389/fvets.2020.00450
- Fluticasone propionate aerosol is more effective for prevention than treatment of recurrent airway obstruction, Robinson N.E. et al. (2009), https://pubmed.ncbi.nlm.nih.gov/19747193/
- Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma, Bullone M. et al. (2017), https://doi.org/10.1038/s41598-017-09414-8
- Glucocorticoid treatment in horses with asthma: A narrative review, Mainguy-Seers S., Lavoie J.-P. (2021), https://doi.org/10.1111/jvim.16189
- Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial, Pirie R.S. et al. (2021), https://doi.org/10.1111/evj.13419
- Inflammatory airway disease of horses – revised Consensus statement, Couëtil L.L. et al. (2016), https://doi.org/10.1111/jvim.13824
- Effects of Bedding Materials on Equine Lower Airway Inflammation, Mönki J. et al. (2021), https://www.frontiersin.org/articles/10.3389/fvets.2021.799645/full
- Recurrent airway obstruction: A review, Pirie R.S. (2014), https://doi.org/10.1111/evj.12204
- Towards personalized medicine for the treatment of equine asthma, Couëtil L.L. et al. (2024), https://doi.org/10.1016/j.tvjl.2024.106125
- Use of inhaled ciclesonide for treatment of moderate asthma in Thoroughbred racehorses, Sanz E. et al. (2025), https://doi.org/10.1111/jvim.17267